Frequently Asked Questions (FAQs)

How long does the Rituxan Immunology and ACTEMRA Co-pay Card Program last?

You may receive up to $15,000 in assistance per 12-month period. Program benefits reset every 12 months from date of enrollment as long as you remain eligible.

If I switch from one Genentech medicine to the other, do I have to reapply to the program?

Yes. Each card can be used for either Rituxan or ACTEMRA only. If you switch to a different Genentech medicine, you must reapply to receive assistance for the new medicine.

What if I forgot to apply and have already received treatment?

You must be enrolled in the program before your treatment. However, under certain circumstances, an exception may be possible. Please call (855) RA-COPAY (855-722-6729) for more information.

How many treatments does the program cover?

There is no limit to the number of Rituxan or ACTEMRA treatments the program covers. Treatments will be covered until the $15,000 limit is reached.

Does the program help with the costs of the intravenous (IV) infusion or doctor's visits?

No. The program only helps with the drug co-pay for Rituxan. It does not help with other costs, like IV infusions or doctor's visits.

Can I use the program if I am taking Rituxan for granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) or pemphigus vulgaris (PV)?

Yes. The program is available to all eligible commercially insured patients taking Rituxan for an FDA-approved indication.

What if I forget to bring the card to the appointment?

You can call (855) RA-COPAY (855-722-6729) from your doctor's office. The help desk hours are from 6 a.m.–5 p.m. PT, Monday through Friday, except major holidays. We will give the account number over the phone.

May I use the Rituxan Immunology Co-pay Card Program at an outside infusion center?

Yes. You may use the program anywhere you get your Rituxan treatments as long as your infusion center accepts the card.

Will I be asked for other information once I'm enrolled in the program?

Yes. You will be asked to send copies of your detailed Explanation of Benefits (EOB) statements after each infusion or injection. This information is required to fund the card.

Can I use the Genentech Patient Foundation and the Rituxan Immunology Co-pay Card Program at the same time?

No. Patients who are receiving free medicine from Genentech Patient Foundation or other patient assistance programs cannot use the Rituxan Immunology Co-pay Card Program. Call (866) 681-3261 or visit to learn more about Genentech Patient Foundation and other patient assistance programs from Genentech Rheumatology Access Solutions.

Can I get a refund from a health plan for the co-pay paid by the card?

No. You cannot receive a refund from a health plan or anyone else for the amount paid by the card.

How do I find out how much money is left on the card?

You can log in to your account to learn your card balance and expiration dates. You can also call (855) RA-COPAY (855-722-6729) from 6 a.m.–5 p.m. PT, Monday through Friday, except major holidays.

How much time do I have to submit a claim?

You have 365 days from your claim's date of service to submit the claim.

If you have any additional questions, please call (855) RA-COPAY (855-722-6729) from 6 a.m.–5 p.m. PT, Monday through Friday, except major holidays.

Indication and Important Safety Information

Rituxan is a prescription medicine used to treat adults with:

Rheumatoid arthritis (RA): with another prescription medicine called methotrexate, to reduce the signs and symptoms of moderate to severe active RA in adults, after treatment with at least one other medicine called a tumor necrosis factor (TNF) antagonist has been used and did not work well enough.

Granulomatosis with Polyangiitis (GPA) (Wegener's Granulomatosis) and Microscopic Polyangiitis (MPA): with glucocorticoids.

Pemphigus Vulgaris (PV): to treat moderate to severe PV.

It is not known if Rituxan is safe and effective in children.

What is the most important information I should know about Rituxan?

Rituxan can cause serious side effects that can lead to death, including:

  • Infusion-Related Reactions: Infusion-related reactions are very common side effects of Rituxan treatment. Serious infusion-related reactions can happen during your infusion or within 24 hours after your infusion of Rituxan. Your healthcare provider should give you medicines before your infusion of Rituxan to decrease your chance of having a severe infusion-related reaction
  • Severe Skin and Mouth Reactions: Tell your healthcare provider or get medical help right away if you get any of these symptoms at any time during your treatment with Rituxan: painful sores or ulcers on your skin, lips, or in your mouth; blisters; peeling skin; rash; or pustules
  • Hepatitis B Virus (HBV) Reactivation: If you have had hepatitis B or are a carrier of hepatitis B virus, receiving Rituxan could cause the virus to become an active infection again. Hepatitis B reactivation may cause serious liver problems, including liver failure and death. You should not receive Rituxan if you have active hepatitis B liver disease. Your healthcare provider will monitor you for hepatitis B infection during and for several months after you stop receiving Rituxan
  • Progressive Multifocal Leukoencephalopathy (PML): PML is a rare, serious brain infection caused by a virus that can happen in people who receive Rituxan. People with weakened immune systems can get PML. PML can result in death or severe disability. There is no known treatment, prevention, or cure for PML

Before receiving Rituxan, patients should tell their healthcare provider if they:

  • have had a severe reaction to Rituxan or a rituximab product
  • currently have or have a history of other medical conditions, especially heart disease
  • have had a severe infection, currently have an infection, or have a weakened immune system
  • have had a recent vaccination or are scheduled to receive vaccinations
  • are pregnant or planning to become pregnant. Females who are able to become pregnant should use effective birth control (contraception) during treatment with Rituxan and for 12 months after the last dose of Rituxan
  • are breastfeeding or plan to breastfeed. Patients should not breastfeed during treatment and for at least 6 months after the last dose of Rituxan
  • are taking any medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements

What are the possible side effects of Rituxan?

Rituxan can cause serious and life-threatening side effects, including:

  • Tumor Lysis Syndrome (TLS): TLS is caused by the fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment or may cause an abnormal heart rhythm. Tell your healthcare provider right away if you have any of the following signs or symptoms of TLS: nausea, vomiting, diarrhea, or lack of energy
  • Serious Infections: Serious infections can happen during and after treatment with Rituxan and can lead to death. Rituxan can increase your risk of getting infections and can lower the ability of your immune system to fight infections. People with serious infections should not receive Rituxan
  • Heart Problems: Rituxan may cause chest pain, irregular heartbeats, and heart attack. Your healthcare provider may monitor your heart during and after treatment with Rituxan if you have symptoms of heart problems or have a history of heart problems
  • Kidney Problems: especially if you are receiving Rituxan for non-Hodgkin's lymphoma (NHL). Your healthcare provider should do blood tests to check how well your kidneys are working
  • Stomach and Serious Bowel Problems That Can Sometimes Lead to Death: Tell your healthcare provider right away if you have any stomach-area pain during treatment with Rituxan

What are common side effects during treatment with Rituxan?

The most common side effects of Rituxan include:

  • infusion-related reactions
  • infections (may include fever, chills)
  • body aches
  • tiredness
  • nausea

In patients with GPA or MPA, the most common side effects of Rituxan also include:

  • low white and red blood cells
  • swelling
  • diarrhea
  • muscle spasms

Other side effects with Rituxan include:

  • aching joints during or within hours of receiving an infusion
  • more frequent upper respiratory tract infections

These are not all of the possible side effects with Rituxan.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at (800) FDA-1088 or You may also report side effects to Genentech at (888) 835-2555.

Please see the Rituxan Prescribing Information and Medication Guide including Most Serious Side Effects for additional Important Side Effect Information.