Welcome to the Genentech Rheumatology Co-pay Card Program

What does Rituxan treat?

Rheumatoid arthritis (RA): with another prescription medicine called methotrexate, to reduce the signs and symptoms of moderate to severe active RA in adults, after treatment with at least one other medicine called a tumor necrosis factor (TNF) antagonist has been used and did not work well enough.

Granulomatosis with Polyangiitis (GPA) (Wegener's Granulomatosis) and Microscopic Polyangiitis (MPA): with glucocorticoids, to treat GPA and MPA.

People with serious infections should not receive Rituxan. It is not known if Rituxan is safe or effective in children.

What is the most important information I should know about Rituxan?

Rituxan can cause serious side effects that can lead to death, including:

• Infusion reactions: Infusion reactions are the most common side effect of Rituxan treatment. Serious infusion reactions can happen during your infusion or within 24 hours after your infusion
• Severe skin and mouth reactions: painful sores or ulcers on your skin, lips or in your mouth, blisters, peeling skin, rash, pustules
• Hepatitis B virus (HBV) reactivation: If you have had hepatitis B or are a carrier of hepatitis B virus, receiving Rituxan could cause the virus to become an active infection again
• Progressive multifocal leukoencephalopathy (PML): a rare, serious brain infection caused by a virus

What are the possible side effects of Rituxan?

Rituxan can cause serious and life-threatening side effects, including:

• Tumor lysis syndrome (TLS): TLS is caused by the fast breakdown of cancer cells. TLS can cause you to have kidney failure and the need for dialysis treatment or may cause an abnormal heart rhythm
• Serious infections: Serious infections can happen during and after treatment with Rituxan and can lead to death
• Heart problems: Rituxan may cause chest pain and irregular heartbeats, which may need treatment, or your doctor may decide to stop your treatment with Rituxan
• Kidney problems: especially if you are receiving Rituxan for NHL. Your doctor should do blood tests to check how well your kidneys are working
• Stomach and serious bowel problems that can sometimes lead to death: Tell your doctor right away if you have any stomach area pain during treatment with Rituxan
• Low blood cell counts: Your doctor may do blood tests during treatment with Rituxan to check your blood cell counts

What are common side effects during treatment with Rituxan?

• infusion reactions
• chills
• infections
• body aches
• tiredness
• low white blood cells

Other side effects include:

• aching joints during or within hours of receiving an infusion
• more frequent upper respiratory tract infection

You may report side effects to the FDA at (800) FDA-1088 or www.FDA.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.

Please see the Rituxan full Prescribing Information, including Medication Guide including most serious side effects for additional important safety information.

ACTEMRA INDICATIONS

ACTEMRA is a prescription medicine called an interleukin-6 (IL-6) receptor antagonist. ACTEMRA is used to treat:

• Adults with moderately to severely active rheumatoid arthritis (RA) after at least one other medicine called a Disease Modifying Anti-Rheumatic Drug (DMARD) has been used and did not work well
• Patients with active polyarticular juvenile idiopathic arthritis (PJIA) or active systemic juvenile idiopathic arthritis (SJIA) 2 years of age and older

ACTEMRA IMPORTANT SAFETY INFORMATION

ACTEMRA can cause serious side effects.
ACTEMRA changes the way your immune system works. This can make you more likely to get infections or make any current infection worse. Some people taking ACTEMRA have died from these infections.

ACTEMRA can cause other serious side effects including stomach tears; changes in blood test results that check for low neutrophil and platelet counts, and increases in certain liver function test levels and blood cholesterol levels; increased risk of certain cancers by changing the way your immune system works; hepatitis B infection; serious allergic reactions, including death (these may happen with ACTEMRA infusions or injections, even if they did not occur with an earlier infusion or injection); and nervous system problems.

Tell your doctor if you're allergic to ACTEMRA or if you've had a bad reaction to ACTEMRA previously.

Common side effects in patients with RA include upper respiratory tract infections (like common cold and sinus infections), headache, increased blood pressure (also called hypertension), and injection site reactions. Tell your doctor if you have these or any other side effect that bothers you or does not go away.

Common side effects in patients with PJIA or SJIA include upper respiratory tract infections (common cold, sinus infections), headache, and diarrhea.

Tell your doctor if you are planning to become pregnant, are pregnant, plan to breast-feed, or are breast-feeding. You and your doctor should decide if you will take ACTEMRA or breast-feed. You should not do both. If you are pregnant and taking ACTEMRA, join the pregnancy registry. To learn more, call 1-877-311-8972 or talk to your doctor to register.

Tell your doctor right away if you are experiencing any side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.FDA.gov/medwatch. You may also call Genentech at 1-888-835-2555.

Please see ACTEMRA full Prescribing Information, including Medication Guide and Serious Side Effects, for more Important Safety Information.

Rituxan^® and its logo are registered trademarks of Biogen Idec, Inc.

ACTEMRA^® and its logo are registered trademarks of Chugai Seiyaku Kabushiki Kaisha Corp., a member of the Roche Group.

The Rituxan Prepaid MasterCard and ACTEMRA Prepaid MasterCard are issued by The Bancorp Bank pursuant to license by MasterCard International Incorporated. MasterCard is a registered trademark of MasterCard International Incorporated. These cards may not be used everywhere Debit MasterCard is accepted. No cash or ATM access. The Bancorp Bank; Member FDIC.